June 19

Histamine Intolerance: A Surprising Cause Of Inflammation

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What are symptoms of histamine intolerance?

Histamine intolerance is basically an allergic reaction without the allergen, sometimes called a “pseudoallergy.” The typical symptoms of histamine intolerance are similar to allergic reactions (like rash, trouble breathing, and a runny nose) but also go beyond your typical sneezing, to include:

  • anxiety
  • brain fog
  • digestive problems
  • eczema
  • fatigue
  • hormone imbalances
  • irritability
  • low blood pressure
  • low sex drive
  • migraines
  • nausea
  • racing heart

If you typically experience any of these symptoms after eating high histamine foods, you may have a histamine intolerance.

Foods to avoid with histamine intolerance:

High-histamine foods

These foods could cause an overload of histamine:

  • Alcohol (including wine)
  • Bone broth
  • Canned food
  • Cheese
  • Chocolate
  • Eggplant
  • Fermented food (kefir, kimchi, yogurt, sauerkraut)
  • Legumes (soybeans, chickpeas, peanuts)
  • Mushrooms
  • Nuts
  • Processed foods
  • Smoked meat products (bacon, salami, salmon, ham)
  • Shellfish
  • Spinach
  • Vinegar

Foods that release histamine

These foods are low in histamines but can trigger the release of histamine and create problems for people with histamine intolerance:

  • Avocados
  • Bananas
  • Citrus fruits (kiwi, lemon, lime, papayas, pineapple, plums)
  • Strawberries
  • Tomatoes

Diamine Oxidase (DAO) enzyme blockers

These foods block the enzyme that controls histamine:

  • Alcohol
  • Energy drinks
  • Teas (black, green, yerba)

What to do if you have histamine intolerance:

If you struggle with the symptoms above or find that these foods give you problems, here’s what I recommend:

1. Find out for sure.

In my functional medicine clinic I run labs to look for a high histamine/DAO ratio. This suggests that you’re eating too many histamine-rich foods for your body, and that you don’t have enough enzymes to break them down.

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2. Get to the root of the problem.

Why might people have histamine intolerance in the first place? As a functional medicine practitioner, my goal is to get to the root cause of inflammatory problems like histamine intolerance. A few common possibilities:

3. Eliminate your problem foods.

An elimination diet is the gold standard for uncovering foods that trigger inflammation for you. The elimination diet I cover in my mindbodygreen video course is low-histamine-friendly. I’ll walk you through how to reintroduce foods after a period of elimination time to find out which ones are causing you problems.

4. Focus on eating fresh foods.

Bacterial growth in foods left unrefrigerated can increase histamine. Eat fresh foods and freeze leftover immediately in single-serve portions.

For a low-histamine diet, focus on these foods:

  • Coconut milk
  • Egg yolk
  • Fresh wild-caught fish
  • Fresh organic meat
  • Fresh vegetables (except eggplants, tomatoes, and spinach)
  • Gluten-free grains (rice, corn)
  • Herbal teas
  • Non-citrus fresh fruits
  • Rice milk

5. Heal your gut.

Microbiome imbalances can also release histamine and trigger symptoms. Problems like leaky gut syndromeSIBO, and candida overgrowth could be fueling your histamine intolerance.

Probiotics can help. In one study, two strains of bifidobacterium suppressed histamine release, and in another, Lactobacillus rhamnosus suppressed histamine receptors.

Note: Certain probiotic supplements, especially those containing prebiotics, won’t agree with you if you have bacterial overgrowths.

6. Eat foods that help your body get rid of excess histamines.

Increase your intake of foods with vitamin B6, vitamin C, and copper.

Vitamin B6: chicken, turkey, and potatoes

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Copper: asparagus and liver

Vitamin C: fruits and vegetables (except for those high in histamine)

Black cumin and quercetin are also two natural medicines that have antihistamine properties



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